The Biostatistics Facility provides statistical expertise in study design and data analysis for members of UPCI. Statisticians within the unit collaborate on developing protocols for clinical trials, and research proposals for laboratory-based investigations, epidemiologic studies, and clinical investigations. We perform statistical analyses for such studies, substantively interpret their results, and author or co author papers for publication. The Facility is committed to developing statistical methodology that aids cancer research, and to applying statistical and computational methods to accomplish this.
Study design
 |
Advise on statistical aspects of the design of laboratory-based studies, clinical trials, clinical investigations, epidemiologic studies, and population-based studies such as screening programs |
|
Formulate study objectives and endpoints in terms that are appropriate for statistical analysis |
|
Recommend and implement novel statistical methods, such as adaptive dose-finding techniques for phase I clinical trials |
|
Propose and implement alternative designs for phase II clinical trials |
|
Determine sample size needed to address study objectives at an appropriate level of significance, power, or false-discovery rate |
|
Develop and write plans for statistical analyses |
|
Develop and implement randomization procedures |
Data analysis
|
Analysis of diagnostic & screening tests |
|
Assessment of prognostic markers |
|
Bayesian estimation |
|
Evaluation of cancer patients' quality of life in clinical trials |
|
Interim monitoring of clinical trials using frequentist or Bayesian methodology |
|
Kaplan-Meier estimation |
|
Linear, nonlinear, and multiple regression |
|
Logistic, polytomous, and Poisson regression |
|
Logic regression |
|
Meta-analysis |
|
Mixed models |
|
Nonparametric estimation |
|
Proportional hazards regression |
|
Repeated measures analysis |